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In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
BACKGROUND: Thalidomide and its analogs, lenalidomide and pomalidomide (referred to as immunomodulatory imide drugs or IMiDs) have been known to treat multiple myeloma and other hematologic malignancies as well as to cause teratogenicity. Recently the protein cereblon was identified as the primary t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949186/ https://www.ncbi.nlm.nih.gov/pubmed/27478739 http://dx.doi.org/10.1186/s40064-016-2761-9 |