A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance

Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.(1–3) Insulin resistance in skeletal muscle stems from excess accumulation of lipid species(4), a process that requires...

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Detalles Bibliográficos
Autores principales: Jang, Cholsoon, Oh, Sungwhan F, Wada, Shogo, Rowe, Glenn C, Liu, Laura, Chan, Mun Chun, Rhee, James, Hoshino, Atsushi, Kim, Boa, Ibrahim, Ayon, Baca, Luisa G, Kim, Esl, Ghosh, Chandra C, Parikh, Samir M, Jiang, Aihua, Chu, Qingwei, Forman, Daniel E., Lecker, Stewart H., Krishnaiah, Saikumari, Rabinowitz, Joshua D, Weljie, Aalim M, Baur, Joseph A, Kasper, Dennis L, Arany, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949205/
https://www.ncbi.nlm.nih.gov/pubmed/26950361
http://dx.doi.org/10.1038/nm.4057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949205/
https://www.ncbi.nlm.nih.gov/pubmed/26950361
http://dx.doi.org/10.1038/nm.4057

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