Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease

Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specifica...

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Autores principales: Boije, Henrik, Shirazi Fard, Shahrzad, Edqvist, Per-Henrik, Hallböök, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949263/
https://www.ncbi.nlm.nih.gov/pubmed/27486389
http://dx.doi.org/10.3389/fnana.2016.00077
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author Boije, Henrik
Shirazi Fard, Shahrzad
Edqvist, Per-Henrik
Hallböök, Finn
author_facet Boije, Henrik
Shirazi Fard, Shahrzad
Edqvist, Per-Henrik
Hallböök, Finn
author_sort Boije, Henrik
collection PubMed
description Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis.
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spelling pubmed-49492632016-08-02 Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease Boije, Henrik Shirazi Fard, Shahrzad Edqvist, Per-Henrik Hallböök, Finn Front Neuroanat Neuroscience Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis. Frontiers Media S.A. 2016-07-19 /pmc/articles/PMC4949263/ /pubmed/27486389 http://dx.doi.org/10.3389/fnana.2016.00077 Text en Copyright © 2016 Boije, Shirazi Fard, Edqvist and Hallböök. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Boije, Henrik
Shirazi Fard, Shahrzad
Edqvist, Per-Henrik
Hallböök, Finn
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title_full Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title_fullStr Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title_full_unstemmed Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title_short Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
title_sort horizontal cells, the odd ones out in the retina, give insights into development and disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949263/
https://www.ncbi.nlm.nih.gov/pubmed/27486389
http://dx.doi.org/10.3389/fnana.2016.00077
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