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Influence of chelator and near-infrared dye labeling on biocharacteristics of dual-labeled trastuzumab-based imaging agents

OBJECTIVE: To investigate the effect of fluorescent dye labeling on the targeting capabilities of 111In- (DTPA)n-trastuzumab-(IRDye 800)m. METHODS: Trastuzumab-based conjugates were synthesized and conjugated with diethylenetriaminepentaacetic acid (DTPA) at molar ratios of 1, 2, 3 and 5 and with a...

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Detalles Bibliográficos
Autores principales:	Wang, Xuejuan, Aldrich, Melissa B, Yang, Zhi, Zhou, Nina, Xie, Qing, Liu, Chen, Sevick-Muraca, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949282/ https://www.ncbi.nlm.nih.gov/pubmed/27478322 http://dx.doi.org/10.21147/j.issn.1000-9604.2016.03.11

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