Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency

Polycomb repressive complex 2 (PRC2) participates in transcriptional repression through methylation of histone H3K27. The WD-repeat protein embryonic ectoderm development (EED) is a non-catalytic but an essential component of PRC2 and its mutations were identified in hematopoietic malignancies. To c...

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Detalles Bibliográficos
Autores principales: Ikeda, Kenichiro, Ueda, Takeshi, Yamasaki, Norimasa, Nakata, Yuichiro, Sera, Yasuyuki, Nagamachi, Akiko, Miyama, Takahiko, Kobayashi, Hiroshi, Takubo, Keiyo, Kanai, Akinori, Oda, Hideaki, Wolff, Linda, Honda, Zen-ichiro, Ichinohe, Tatsuo, Matsubara, Akio, Suda, Toshio, Inaba, Toshiya, Honda, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949429/
https://www.ncbi.nlm.nih.gov/pubmed/27432459
http://dx.doi.org/10.1038/srep29454

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