Cargando…

Cannabinoid receptor subtype 2 (CB(2)R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells

Emerging evidence demonstrates that the blockade of intracellular Ca(2+) signals may protect pancreatic acinar cells against Ca(2+) overload, intracellular protease activation, and necrosis. The activation of cannabinoid receptor subtype 2 (CB(2)R) prevents acinar cell pathogenesis in animal models...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Zebing, Wang, Haiyan, Wang, Jingke, Zhao, Mengqin, Sun, Nana, Sun, Fangfang, Shen, Jianxin, Zhang, Haiying, Xia, Kunkun, Chen, Dejie, Gao, Ming, Hammer, Ronald P., Liu, Qingrong, Xi, Zhengxiong, Fan, Xuegong, Wu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949433/ https://www.ncbi.nlm.nih.gov/pubmed/27432473 http://dx.doi.org/10.1038/srep29757

Ejemplares similares

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms
por: Takheaw, Nuchjira, et al.
Publicado: (2023)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

The Neuroprotective Effects of the CB2 Agonist GW842166x in the 6-OHDA Mouse Model of Parkinson’s Disease
por: Yu, Hao, et al.
Publicado: (2021)

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity
por: Franks, Lirit N., et al.
Publicado: (2016)

Evaluation of carboxamide-type synthetic cannabinoids as CB(1)/CB(2) receptor agonists: difference between the enantiomers
por: Doi, Takahiro, et al.
Publicado: (2017)

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
por: Finlay, David B., et al.
Publicado: (2022)

Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB(2) Receptor
por: Taylor, Lewis, et al.
Publicado: (2015)

CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice
por: Liu, Xiaojie, et al.
Publicado: (2022)

Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB(2) receptor agonist ABK5
por: Tang, Yaliang, et al.
Publicado: (2020)

Characterization of Subtype Selective Cannabinoid CB(2) Receptor Agonists as Potential Anti-Inflammatory Agents
por: Tang, Yaliang, et al.
Publicado: (2021)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
por: Polini, Beatrice, et al.
Publicado: (2020)

Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists
por: Navarro-Dorado, Jorge, et al.
Publicado: (2016)

Antiallodynic Effects of Cannabinoid Receptor 2 (CB(2)R) Agonists on Retrovirus Infection-Induced Neuropathic Pain
por: Sheng, Wen S., et al.
Publicado: (2019)

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties
por: de Oliveira, Daniela R., et al.
Publicado: (2022)

A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats
por: Goonawardena, Anushka V., et al.
Publicado: (2011)

The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone‐Induced Central Nervous System Demyelination
por: Tomas‐Roig, Jordi, et al.
Publicado: (2016)

Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking
por: Gamaleddin, Islam, et al.
Publicado: (2012)

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells
por: Capozzi, Antonella, et al.
Publicado: (2018)

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects
por: Hu, Si-Jing, et al.
Publicado: (2022)

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells
por: Gado, Francesca, et al.
Publicado: (2022)

Effects of the cannabinoid CB(1) agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs
por: Berger, Joel I., et al.
Publicado: (2017)

Time-Dependent Protection of CB2 Receptor Agonist in Stroke
por: Yu, Seong-Jin, et al.
Publicado: (2015)

Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
por: Manzanedo, Carmen, et al.
Publicado: (2010)

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
por: Capozzi, Antonella, et al.
Publicado: (2021)

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966
por: Reichenbach, Zachary W., et al.
Publicado: (2022)

Cannabinoid Receptor 2 (CB2) Inverse Agonist SMM-189 Induces Expression of Endogenous CB2 and Protein Kinase A That Differentially Modulates the Immune Response and Suppresses Experimental Colitis
por: Kiran, Sonia, et al.
Publicado: (2022)

Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias
por: Sharma, Raahul, et al.
Publicado: (2023)

Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists
por: Cho, Analia Young Hwa, et al.
Publicado: (2023)

Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway
por: Yang, Shuai, et al.
Publicado: (2020)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Cannabinoids: A New Group of Agonists of PPARs
por: Sun, Yan, et al.
Publicado: (2007)

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals
por: Niu, Ho-Shan, et al.
Publicado: (2015)

Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats
por: Wang, Jie-ping, et al.
Publicado: (2022)

PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells
por: Wojtowicz, Anna K., et al.
Publicado: (2013)

Cannabinoid CB(1) Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats
por: Zheng, Yiwen, et al.
Publicado: (2015)

Involvement of the CB(2) cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma
por: Khan, Mohammed I., et al.
Publicado: (2018)

EVs-mediated delivery of CB2 receptor agonist for Alzheimer's disease therapy
por: Zhu, Yanjing, et al.
Publicado: (2023)

Stimulation of cannabinoid receptor 2 (CB(2)) suppresses microglial activation
por: Ehrhart, Jared, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_fb16hsu0vl7li8ievks1vfcc8c