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F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2

NLRP3 and ASC are able to form a large multimeric complex called inflammasome in response to a number danger signals. The NLRP3 inflammasome is required for the activation of caspase-1 and subsequent maturation of pro-IL-1β into active IL-1β. Although the mechanisms regulating the formation and acti...

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Detalles Bibliográficos
Autores principales:	Burger, Danielle, Fickentscher, Céline, de Moerloose, Philippe, Brandt, Karim J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949445/ https://www.ncbi.nlm.nih.gov/pubmed/27431477 http://dx.doi.org/10.1038/srep29834

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