53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

In normal human cells, centrosome loss induced by centrinone—a specific centrosome duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown mechanism. A genome-wide CRISPR/Cas9 screen for centrinone resistance identified genes encoding the p53-binding protein 53BP1, the deu...

Descripción completa

Detalles Bibliográficos
Autores principales: Meitinger, Franz, Anzola, John V., Kaulich, Manuel, Richardson, Amelia, Stender, Joshua D., Benner, Christopher, Glass, Christopher K., Dowdy, Steven F., Desai, Arshad, Shiau, Andrew K., Oegema, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949453/
https://www.ncbi.nlm.nih.gov/pubmed/27432897
http://dx.doi.org/10.1083/jcb.201604081

Ejemplares similares

Ejemplares similares