Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting

Targeted delivery of antithrombotic drugs centralizes the effects in the thrombosis site and reduces the hemorrhage side effects in uninjured vessels. We have recently reported that the platelet-targeting factor Xa (FXa) inhibitors, constructed by engineering one Arg-Gly-Asp (RGD) motif into Ancylos...

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Detalles Bibliográficos
Autores principales: Zhu, Yuanjun, Li, Ruyi, Lin, Yuan, Shui, Mengyang, Liu, Xiaoyan, Chen, Huan, Wang, Yinye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949463/
https://www.ncbi.nlm.nih.gov/pubmed/27432161
http://dx.doi.org/10.1038/srep29895

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