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Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

Ligand efficiency has proven to be a valuable concept for optimization of leads in the early stages of drug design. Taking this one step further, group efficiency (GE) evaluates the binding efficiency of each appendage of a molecule, further fine‐tuning the drug design process. Here, GE analysis is...

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Detalles Bibliográficos
Autores principales:	Hung, Alvin W., Silvestre, H. Leonardo, Wen, Shijun, George, Guillaume P. C., Boland, Jennifer, Blundell, Tom L., Ciulli, Alessio, Abell, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949533/ https://www.ncbi.nlm.nih.gov/pubmed/26486566 http://dx.doi.org/10.1002/cmdc.201500414

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