Interactions between N‐linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin inclusion bodies (FENIB). Neuroserpin is a glycoprotein with predicted glycosy...

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Detalles Bibliográficos
Autores principales: Moriconi, Claudia, Ordoñez, Adriana, Lupo, Giuseppe, Gooptu, Bibek, Irving, James A., Noto, Rosina, Martorana, Vincenzo, Manno, Mauro, Timpano, Valentina, Guadagno, Noemi A., Dalton, Lucy, Marciniak, Stefan J., Lomas, David A., Miranda, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949553/
https://www.ncbi.nlm.nih.gov/pubmed/26367528
http://dx.doi.org/10.1111/febs.13517

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