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Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H‐transfer reactions?

The temperature dependence of kinetic isotope effects (KIEs) has emerged as the main experimental probe of enzymatic H‐transfer by quantum tunnelling. Implicit in the interpretation is a presumed role for dynamic coupling of H‐transfer chemistry to the protein environment, the so‐called ‘promoting m...

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Detalles Bibliográficos
Autores principales:	Hoeven, Robin, Heyes, Derren J., Hay, Sam, Scrutton, Nigel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949571/ https://www.ncbi.nlm.nih.gov/pubmed/25581554 http://dx.doi.org/10.1111/febs.13193

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