Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy

Impairment of the autophagy–lysosome pathway is implicated with the changes in α‐synuclein and mitochondrial dysfunction observed in Parkinson's disease (PD). Damaged mitochondria accumulate PINK1, which then recruits parkin, resulting in ubiquitination of mitochondrial proteins. These can then...

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Detalles Bibliográficos
Autores principales: Ivankovic, Davor, Chau, Kai‐Yin, Schapira, Anthony H. V., Gegg, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949652/
https://www.ncbi.nlm.nih.gov/pubmed/26509433
http://dx.doi.org/10.1111/jnc.13412

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