New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

BACKGROUND: EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is likely confined to various types of cancer, particularly glioblastomas. Althou...

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Detalles Bibliográficos
Autores principales: Atsumi, Sonoko, Nosaka, Chisato, Adachi, Hayamitsu, Kimura, Tomoyuki, Kobayashi, Yoshihiko, Takada, Hisashi, Watanabe, Takumi, Ohba, Shun-ichi, Inoue, Hiroyuki, Kawada, Manabu, Shibasaki, Masakatsu, Shibuya, Masabumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949881/
https://www.ncbi.nlm.nih.gov/pubmed/27431653
http://dx.doi.org/10.1186/s12885-016-2521-9

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