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Expression of evolutionarily novel genes in tumors
The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement i...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949931/ https://www.ncbi.nlm.nih.gov/pubmed/27437030 http://dx.doi.org/10.1186/s13027-016-0077-6 |
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| author | Kozlov, A. P. |
| author_facet | Kozlov, A. P. |
| author_sort | Kozlov, A. P. |
| collection | PubMed |
| description | The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new functions beneficial to organisms. It is suggested to consider the expression of evolutionarily young or novel genes in tumors as a new biological phenomenon, a phenomenon of TSEEN (tumor specifically expressed, evolutionarily novel) genes. |
| format | Online Article Text |
| id | pubmed-4949931 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49499312016-07-20 Expression of evolutionarily novel genes in tumors Kozlov, A. P. Infect Agent Cancer Review The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new functions beneficial to organisms. It is suggested to consider the expression of evolutionarily young or novel genes in tumors as a new biological phenomenon, a phenomenon of TSEEN (tumor specifically expressed, evolutionarily novel) genes. BioMed Central 2016-07-19 /pmc/articles/PMC4949931/ /pubmed/27437030 http://dx.doi.org/10.1186/s13027-016-0077-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Kozlov, A. P. Expression of evolutionarily novel genes in tumors |
| title | Expression of evolutionarily novel genes in tumors |
| title_full | Expression of evolutionarily novel genes in tumors |
| title_fullStr | Expression of evolutionarily novel genes in tumors |
| title_full_unstemmed | Expression of evolutionarily novel genes in tumors |
| title_short | Expression of evolutionarily novel genes in tumors |
| title_sort | expression of evolutionarily novel genes in tumors |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949931/ https://www.ncbi.nlm.nih.gov/pubmed/27437030 http://dx.doi.org/10.1186/s13027-016-0077-6 |
| work_keys_str_mv | AT kozlovap expressionofevolutionarilynovelgenesintumors |