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Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report
The present study aimed to explore the stability, curability and sequelae of cases of Trichloroethylene (TCE) Hypersensitivity Syndrome (THS), and to investigate the causal allergens of THS. Two cases of THS were followed-up in the current study; both cases were healing following glucocorticoid ther...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950263/ https://www.ncbi.nlm.nih.gov/pubmed/27446293 http://dx.doi.org/10.3892/etm.2016.3357 |
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author | Huang, Yong-Shun Huang, Han-Lin Wu, Qi-Feng Xia, Li-Hua Huang, Ming Qiu, Xin-Xiang Zhou, Shan-Yu |
author_facet | Huang, Yong-Shun Huang, Han-Lin Wu, Qi-Feng Xia, Li-Hua Huang, Ming Qiu, Xin-Xiang Zhou, Shan-Yu |
author_sort | Huang, Yong-Shun |
collection | PubMed |
description | The present study aimed to explore the stability, curability and sequelae of cases of Trichloroethylene (TCE) Hypersensitivity Syndrome (THS), and to investigate the causal allergens of THS. Two cases of THS were followed-up in the current study; both cases were healing following glucocorticoid therapy and were discharged >10 weeks prior to follow-up. A questionnaire investigation, health examination and patch test were performed. Allergens of TCE and its metabolites, including chloral hydrate, trichloroethanol (TCOH) and trichloroacetic acid, were applied in the patch test; 4 controls were included. The two subjects were experiencing itching, pigmentation and xerosis of the skin, and had abnormal results in the ophthalmology Schirmer I test and tear break-up time. The body temperature, liver function, superficial lymph nodes, blood, urine routine and autoimmune antibodies of two subjects were shown to be normal, and no new rashes had appeared. All mass concentration of chloral hydrate and TCOH were positive; 5.0% trichloroacetic acid was weakly positive, 0.5% trichloroacetic acid and all mass concentration of TCE were negative. All patch tests were negative in the 4 control subjects. The results suggest that THS was stable following treatment with glucocorticoid therapy. Dry eye syndrome may continue as a sequelae of THS. The patch test demonstrated that the mechanism underlying THS is delayed-type hypersensitivity induced by TCE. In addition, as the hypersensitivity state in a THS rehabilitee could be sustained over a long period of time, it suggests that the metabolites of TCE, not TCE itself, are responsible for THS. Therefore, patients with THS should avoid contact with TCE and its metabolites, and avoid using hypnotic and anticonvulsive drugs containing chloral hydra as the primary ingredient. |
format | Online Article Text |
id | pubmed-4950263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-49502632016-07-21 Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report Huang, Yong-Shun Huang, Han-Lin Wu, Qi-Feng Xia, Li-Hua Huang, Ming Qiu, Xin-Xiang Zhou, Shan-Yu Exp Ther Med Articles The present study aimed to explore the stability, curability and sequelae of cases of Trichloroethylene (TCE) Hypersensitivity Syndrome (THS), and to investigate the causal allergens of THS. Two cases of THS were followed-up in the current study; both cases were healing following glucocorticoid therapy and were discharged >10 weeks prior to follow-up. A questionnaire investigation, health examination and patch test were performed. Allergens of TCE and its metabolites, including chloral hydrate, trichloroethanol (TCOH) and trichloroacetic acid, were applied in the patch test; 4 controls were included. The two subjects were experiencing itching, pigmentation and xerosis of the skin, and had abnormal results in the ophthalmology Schirmer I test and tear break-up time. The body temperature, liver function, superficial lymph nodes, blood, urine routine and autoimmune antibodies of two subjects were shown to be normal, and no new rashes had appeared. All mass concentration of chloral hydrate and TCOH were positive; 5.0% trichloroacetic acid was weakly positive, 0.5% trichloroacetic acid and all mass concentration of TCE were negative. All patch tests were negative in the 4 control subjects. The results suggest that THS was stable following treatment with glucocorticoid therapy. Dry eye syndrome may continue as a sequelae of THS. The patch test demonstrated that the mechanism underlying THS is delayed-type hypersensitivity induced by TCE. In addition, as the hypersensitivity state in a THS rehabilitee could be sustained over a long period of time, it suggests that the metabolites of TCE, not TCE itself, are responsible for THS. Therefore, patients with THS should avoid contact with TCE and its metabolites, and avoid using hypnotic and anticonvulsive drugs containing chloral hydra as the primary ingredient. D.A. Spandidos 2016-08 2016-05-18 /pmc/articles/PMC4950263/ /pubmed/27446293 http://dx.doi.org/10.3892/etm.2016.3357 Text en Copyright: © Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Huang, Yong-Shun Huang, Han-Lin Wu, Qi-Feng Xia, Li-Hua Huang, Ming Qiu, Xin-Xiang Zhou, Shan-Yu Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title | Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title_full | Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title_fullStr | Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title_full_unstemmed | Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title_short | Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report |
title_sort | follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950263/ https://www.ncbi.nlm.nih.gov/pubmed/27446293 http://dx.doi.org/10.3892/etm.2016.3357 |
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