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Drug Utilization and Inappropriate Prescribing in Centenarians

OBJECTIVES: To use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100. DESIGN: Population‐based cohort study. SETTING: Primary care database in the United Kingdom, 1990 to 2013. PARTICIPANTS: Individuals reaching the age...

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Autores principales: Hazra, Nisha C., Dregan, Alex, Jackson, Stephen, Gulliford, Martin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950321/
https://www.ncbi.nlm.nih.gov/pubmed/27130965
http://dx.doi.org/10.1111/jgs.14106
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author Hazra, Nisha C.
Dregan, Alex
Jackson, Stephen
Gulliford, Martin C.
author_facet Hazra, Nisha C.
Dregan, Alex
Jackson, Stephen
Gulliford, Martin C.
author_sort Hazra, Nisha C.
collection PubMed
description OBJECTIVES: To use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100. DESIGN: Population‐based cohort study. SETTING: Primary care database in the United Kingdom, 1990 to 2013. PARTICIPANTS: Individuals reaching the age of 100 between 1990 and 2013 (N = 11,084; n = 8,982 women, n = 2,102 men). MEASUREMENTS: Main drug classes prescribed and potentially inappropriate prescribing according to the 2012 American Geriatrics Society Beers Criteria. RESULTS: At the age of 100, 73% of individuals (79% of women, 54% of men) had received one or more prescription drugs, with a median of 7 (interquartile range 0–12) prescription items. The most frequently prescribed drug classes were cardiovascular (53%), central nervous system (CNS) (53%), and gastrointestinal (47%). Overall, 32% of participants (28% of men, 32% of women) who received drug prescriptions may have received one or more potentially inappropriate prescriptions, with temazepam and amitriptyline being the most frequent. CNS prescriptions were potentially inappropriate in 23% of individuals, and anticholinergic prescriptions were potentially inappropriate in 18% of individuals. CONCLUSION: The majority of centenarians are prescribed one or more drug therapies, and the prescription may be inappropriate for up to one‐third of these individuals. Research using EHRs offers opportunities to understand prescribing trends and improve pharmacological care of the oldest adults.
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spelling pubmed-49503212016-07-28 Drug Utilization and Inappropriate Prescribing in Centenarians Hazra, Nisha C. Dregan, Alex Jackson, Stephen Gulliford, Martin C. J Am Geriatr Soc Brief Reports OBJECTIVES: To use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100. DESIGN: Population‐based cohort study. SETTING: Primary care database in the United Kingdom, 1990 to 2013. PARTICIPANTS: Individuals reaching the age of 100 between 1990 and 2013 (N = 11,084; n = 8,982 women, n = 2,102 men). MEASUREMENTS: Main drug classes prescribed and potentially inappropriate prescribing according to the 2012 American Geriatrics Society Beers Criteria. RESULTS: At the age of 100, 73% of individuals (79% of women, 54% of men) had received one or more prescription drugs, with a median of 7 (interquartile range 0–12) prescription items. The most frequently prescribed drug classes were cardiovascular (53%), central nervous system (CNS) (53%), and gastrointestinal (47%). Overall, 32% of participants (28% of men, 32% of women) who received drug prescriptions may have received one or more potentially inappropriate prescriptions, with temazepam and amitriptyline being the most frequent. CNS prescriptions were potentially inappropriate in 23% of individuals, and anticholinergic prescriptions were potentially inappropriate in 18% of individuals. CONCLUSION: The majority of centenarians are prescribed one or more drug therapies, and the prescription may be inappropriate for up to one‐third of these individuals. Research using EHRs offers opportunities to understand prescribing trends and improve pharmacological care of the oldest adults. John Wiley and Sons Inc. 2016-04-30 2016-05 /pmc/articles/PMC4950321/ /pubmed/27130965 http://dx.doi.org/10.1111/jgs.14106 Text en © 2016 The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Hazra, Nisha C.
Dregan, Alex
Jackson, Stephen
Gulliford, Martin C.
Drug Utilization and Inappropriate Prescribing in Centenarians
title Drug Utilization and Inappropriate Prescribing in Centenarians
title_full Drug Utilization and Inappropriate Prescribing in Centenarians
title_fullStr Drug Utilization and Inappropriate Prescribing in Centenarians
title_full_unstemmed Drug Utilization and Inappropriate Prescribing in Centenarians
title_short Drug Utilization and Inappropriate Prescribing in Centenarians
title_sort drug utilization and inappropriate prescribing in centenarians
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950321/
https://www.ncbi.nlm.nih.gov/pubmed/27130965
http://dx.doi.org/10.1111/jgs.14106
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