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The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset

The reduction in ALS Functional Rating Score (ALSFRS) from reported symptom onset to diagnosis is used to estimate rate of disease progression. ALSFRS decline may be non-linear or distorted by drop-outs in therapeutic trials, reducing the reliability of change in slope as an outcome measure. The PRO...

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Detalles Bibliográficos
Autores principales:	Proudfoot, Malcolm, Jones, Ashley, Talbot, Kevin, Al-Chalabi, Ammar, Turner, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950444/ https://www.ncbi.nlm.nih.gov/pubmed/26864085 http://dx.doi.org/10.3109/21678421.2016.1140786

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