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Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies

The aim of the present study was to identify alterations in brain function following administration of a single, low-dose of codeine phosphate in healthy volunteers using resting-state functional magnetic resonance imaging (fMRI). In addition, the metabolic changes in the two sides of the frontal lo...

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Autores principales: Cao, Zhen, Lin, Pei-Yin, Shen, Zhi-Wei, Wu, Ren-Hua, Xiao, Ye-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950574/
https://www.ncbi.nlm.nih.gov/pubmed/27446252
http://dx.doi.org/10.3892/etm.2016.3358
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author Cao, Zhen
Lin, Pei-Yin
Shen, Zhi-Wei
Wu, Ren-Hua
Xiao, Ye-Yu
author_facet Cao, Zhen
Lin, Pei-Yin
Shen, Zhi-Wei
Wu, Ren-Hua
Xiao, Ye-Yu
author_sort Cao, Zhen
collection PubMed
description The aim of the present study was to identify alterations in brain function following administration of a single, low-dose of codeine phosphate in healthy volunteers using resting-state functional magnetic resonance imaging (fMRI). In addition, the metabolic changes in the two sides of the frontal lobe were identified using (1)H-magnetic resonance spectroscopy ((1)H-MRS). A total of 20 right-handed healthy participants (10 males, 10 females) were evaluated, and a Signa HDx 1.5T MRI scanner was used for data acquisition. An echo planar imaging sequence was used for resting-state fMRI, whereas a point resolved spectroscopy sequence was used for (1)H-MRS. Regional Saturation Technique, Data Processing Assistant for Resting-State fMRI, and Statistical Parameter Mapping 8 were used to analyze the fMRI data. The (1)H-MRS data were analyzed using LCModel software. At 1 h after oral administration of codeine phosphate (1.0 mg/kg), the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity were altered in different brain areas. The choline content was significantly increased in the right and left frontal lobes following codeine phosphate administration (P=0.02 and P=0.03, respectively), whereas the inositol content was significantly decreased in the left frontal lobe (P=0.02). There was no change in the glutamic acid content in the frontal lobes. In conclusion, the functions of different brain regions can be affected by a single, low-dose administration of codeine phosphate. The alterations in metabolite content in the two frontal lobes may be associated with changes in brain function, whereas the ALFF in the globus pallidus may have an effect on codeine phosphate addiction. Finally, glutamic acid may be useful in the estimation of codeine dependence.
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spelling pubmed-49505742016-07-21 Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies Cao, Zhen Lin, Pei-Yin Shen, Zhi-Wei Wu, Ren-Hua Xiao, Ye-Yu Exp Ther Med Articles The aim of the present study was to identify alterations in brain function following administration of a single, low-dose of codeine phosphate in healthy volunteers using resting-state functional magnetic resonance imaging (fMRI). In addition, the metabolic changes in the two sides of the frontal lobe were identified using (1)H-magnetic resonance spectroscopy ((1)H-MRS). A total of 20 right-handed healthy participants (10 males, 10 females) were evaluated, and a Signa HDx 1.5T MRI scanner was used for data acquisition. An echo planar imaging sequence was used for resting-state fMRI, whereas a point resolved spectroscopy sequence was used for (1)H-MRS. Regional Saturation Technique, Data Processing Assistant for Resting-State fMRI, and Statistical Parameter Mapping 8 were used to analyze the fMRI data. The (1)H-MRS data were analyzed using LCModel software. At 1 h after oral administration of codeine phosphate (1.0 mg/kg), the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity were altered in different brain areas. The choline content was significantly increased in the right and left frontal lobes following codeine phosphate administration (P=0.02 and P=0.03, respectively), whereas the inositol content was significantly decreased in the left frontal lobe (P=0.02). There was no change in the glutamic acid content in the frontal lobes. In conclusion, the functions of different brain regions can be affected by a single, low-dose administration of codeine phosphate. The alterations in metabolite content in the two frontal lobes may be associated with changes in brain function, whereas the ALFF in the globus pallidus may have an effect on codeine phosphate addiction. Finally, glutamic acid may be useful in the estimation of codeine dependence. D.A. Spandidos 2016-08 2016-05-18 /pmc/articles/PMC4950574/ /pubmed/27446252 http://dx.doi.org/10.3892/etm.2016.3358 Text en Copyright: © Cao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Cao, Zhen
Lin, Pei-Yin
Shen, Zhi-Wei
Wu, Ren-Hua
Xiao, Ye-Yu
Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title_full Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title_fullStr Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title_full_unstemmed Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title_short Alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
title_sort alterations in brain metabolism and function following administration of low-dose codeine phosphate: (1)h-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950574/
https://www.ncbi.nlm.nih.gov/pubmed/27446252
http://dx.doi.org/10.3892/etm.2016.3358
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