A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate

We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remissio...

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Detalles Bibliográficos
Autores principales: Sørensen, Anders Lindholm, Kallenbach, Klaus, Hasselbalch, Hans Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950584/
https://www.ncbi.nlm.nih.gov/pubmed/27489765
http://dx.doi.org/10.1016/j.lrr.2016.06.004
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author Sørensen, Anders Lindholm
Kallenbach, Klaus
Hasselbalch, Hans Carl
author_facet Sørensen, Anders Lindholm
Kallenbach, Klaus
Hasselbalch, Hans Carl
author_sort Sørensen, Anders Lindholm
collection PubMed
description We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
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spelling pubmed-49505842016-08-03 A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate Sørensen, Anders Lindholm Kallenbach, Klaus Hasselbalch, Hans Carl Leuk Res Rep Article We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment. Elsevier 2016-06-27 /pmc/articles/PMC4950584/ /pubmed/27489765 http://dx.doi.org/10.1016/j.lrr.2016.06.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sørensen, Anders Lindholm
Kallenbach, Klaus
Hasselbalch, Hans Carl
A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title_full A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title_fullStr A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title_full_unstemmed A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title_short A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
title_sort remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950584/
https://www.ncbi.nlm.nih.gov/pubmed/27489765
http://dx.doi.org/10.1016/j.lrr.2016.06.004
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