Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

BACKGROUND: Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion to ischemic conditioning. We investigated whether b...

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Detalles Bibliográficos
Autores principales: Giblett, Joel P., Axell, Richard G., White, Paul A., Clarke, Sophie J., McCormick, Liam, Read, Philip A., Reinhold, Johannes, Brown, Adam J., O’Sullivan, Michael, West, Nick E. J., Dutka, David P., Hoole, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950774/
https://www.ncbi.nlm.nih.gov/pubmed/27431258
http://dx.doi.org/10.1186/s12933-016-0416-3

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