In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations

BACKGROUND: Lissencephaly, or smooth brain, is a severe congenital brain malformation that is thought to be associated with impaired neuronal migration during corticogenesis. However, the exact etiology of lissencephaly in humans remains unknown. Research on congenital diseases is limited by the sho...

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Detalles Bibliográficos
Autores principales: Bamba, Yohei, Shofuda, Tomoko, Kato, Mitsuhiro, Pooh, Ritsuko K., Tateishi, Yoko, Takanashi, Jun-ichi, Utsunomiya, Hidetsuna, Sumida, Miho, Kanematsu, Daisuke, Suemizu, Hiroshi, Higuchi, Yuichiro, Akamatsu, Wado, Gallagher, Denis, Miller, Freda D., Yamasaki, Mami, Kanemura, Yonehiro, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950778/
https://www.ncbi.nlm.nih.gov/pubmed/27431206
http://dx.doi.org/10.1186/s13041-016-0246-y

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