Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR

INTRODUCTION: Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR). Fasting regulates the expression of both P450 enzymes and CAR and affects hepatic drug...

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Detalles Bibliográficos
Autores principales: de Vries, E. M., Lammers, L. A., Achterbergh, R., Klümpen, H-J, Mathot, R. A. A., Boelen, A., Romijn, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951123/
https://www.ncbi.nlm.nih.gov/pubmed/27434302
http://dx.doi.org/10.1371/journal.pone.0159552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951123/
https://www.ncbi.nlm.nih.gov/pubmed/27434302
http://dx.doi.org/10.1371/journal.pone.0159552

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