Cargando…

Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR

INTRODUCTION: Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR). Fasting regulates the expression of both P450 enzymes and CAR and affects hepatic drug...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Vries, E. M., Lammers, L. A., Achterbergh, R., Klümpen, H-J, Mathot, R. A. A., Boelen, A., Romijn, J. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951123/ https://www.ncbi.nlm.nih.gov/pubmed/27434302 http://dx.doi.org/10.1371/journal.pone.0159552

Ejemplares similares

Short-Term Fasting Alters Pharmacokinetics of Cytochrome P450 Probe Drugs: Does Protein Binding Play a Role?
por: Lammers, Laureen A., et al.
Publicado: (2017)

Nutritional Status Differentially Alters Cytochrome P450 3A4 (CYP3A4) and Uridine 5′-Diphospho-Glucuronosyltransferase (UGT) Mediated Drug Metabolism: Effect of Short-Term Fasting and High Fat Diet on Midazolam Metabolism
por: Lammers, Laureen A., et al.
Publicado: (2018)

Signaling control of the constitutive androstane receptor (CAR)
por: Yang, Hui, et al.
Publicado: (2014)

Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach
por: Lammers, Laureen A., et al.
Publicado: (2017)

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
por: Küblbeck, Jenni, et al.
Publicado: (2020)

Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation
por: Juang, Shin-Hun, et al.
Publicado: (2020)

Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)
por: Cai, Xinran, et al.
Publicado: (2021)

Deletion of Nuclear Receptor Constitutive Androstane Receptor CAR Increases Anxiety and Lowers Androgen Levels
por: Hernandez, Juan P, et al.
Publicado: (2021)

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists
por: Carazo, Alejandro, et al.
Publicado: (2015)

Noncanonical Constitutive Androstane Receptor Signaling in Gene Regulation
por: Pustylnyak, Yuliya A., et al.
Publicado: (2020)

Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells
por: Zhang, Lei, et al.
Publicado: (2016)

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes
por: McMahon, Michael, et al.
Publicado: (2019)

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation
por: Pinne, Marija, et al.
Publicado: (2016)

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling
por: Carazo, Alejandro, et al.
Publicado: (2018)

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain
por: Skoda, Josef, et al.
Publicado: (2020)

PMON251 Loss of Constitutive Androstane Receptor, CAR reduces the serum androgens levels and alters reproductive function
por: Asokakumar, Anjana, et al.
Publicado: (2022)

β-catenin signaling, the constitutive androstane receptor and their mutual interactions
por: Braeuning, Albert, et al.
Publicado: (2020)

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor
por: Arnold, Katja A, et al.
Publicado: (2004)

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor
por: Lukowicz, Céline, et al.
Publicado: (2019)

Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium
por: López-Riera, Mireia, et al.
Publicado: (2021)

SAT017 Investigating The Spatial Regulation Mediated By Constitutive Androstane Receptor
por: Asokakumar, Anjana, et al.
Publicado: (2023)

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2
por: Bachmann, Fabio, et al.
Publicado: (2021)

Sorafenib for Patients with Hepatocellular Carcinoma and Child‐Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study
por: Labeur, Tim A., et al.
Publicado: (2019)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor
por: MacLeod, A. Kenneth, et al.
Publicado: (2013)

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR)
por: Niu, Congrong, et al.
Publicado: (2021)

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox
por: Saez-Lopez, Cristina, et al.
Publicado: (2017)

Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya
por: Ngayo, Musa Otieno, et al.
Publicado: (2022)

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor
por: Lynch, Caitlin, et al.
Publicado: (2015)

Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor
por: Oliviero, Fabiana, et al.
Publicado: (2020)

Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
por: Chakraborty, S, et al.
Publicado: (2011)

Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)
por: Yamada, Tomoya
Publicado: (2021)

Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptor
por: Kanno, Yuichiro, et al.
Publicado: (2014)

Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor
por: Mathäs, Marianne, et al.
Publicado: (2014)

Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression
por: Ahn, Hwa Young, et al.
Publicado: (2018)

Author Correction: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor
por: Lukowicz, Céline, et al.
Publicado: (2020)

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver
por: Sen, Anushna, et al.
Publicado: (2022)

Author Correction: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox
por: Saez-Lopez, Cristina, et al.
Publicado: (2018)

In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets
por: Niu, Ben, et al.
Publicado: (2018)

SAT007 Excess Bile Acids Can Compensate To Promote Regeneration In Constitutive Androstane Receptor Knockout Mice
por: Zhou, Weinan, et al.
Publicado: (2023)

MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor
por: Shizu, Ryota, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_padguoab6a9rf2fppimrmsqipg