DYT1 dystonia increases risk taking in humans

It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymm...

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Detalles Bibliográficos
Autores principales: Arkadir, David, Radulescu, Angela, Raymond, Deborah, Lubarr, Naomi, Bressman, Susan B, Mazzoni, Pietro, Niv, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951192/
https://www.ncbi.nlm.nih.gov/pubmed/27249418
http://dx.doi.org/10.7554/eLife.14155
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author Arkadir, David
Radulescu, Angela
Raymond, Deborah
Lubarr, Naomi
Bressman, Susan B
Mazzoni, Pietro
Niv, Yael
author_facet Arkadir, David
Radulescu, Angela
Raymond, Deborah
Lubarr, Naomi
Bressman, Susan B
Mazzoni, Pietro
Niv, Yael
author_sort Arkadir, David
collection PubMed
description It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans. DOI: http://dx.doi.org/10.7554/eLife.14155.001
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spelling pubmed-49511922016-07-21 DYT1 dystonia increases risk taking in humans Arkadir, David Radulescu, Angela Raymond, Deborah Lubarr, Naomi Bressman, Susan B Mazzoni, Pietro Niv, Yael eLife Neuroscience It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans. DOI: http://dx.doi.org/10.7554/eLife.14155.001 eLife Sciences Publications, Ltd 2016-06-01 /pmc/articles/PMC4951192/ /pubmed/27249418 http://dx.doi.org/10.7554/eLife.14155 Text en © 2016, Arkadir et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Arkadir, David
Radulescu, Angela
Raymond, Deborah
Lubarr, Naomi
Bressman, Susan B
Mazzoni, Pietro
Niv, Yael
DYT1 dystonia increases risk taking in humans
title DYT1 dystonia increases risk taking in humans
title_full DYT1 dystonia increases risk taking in humans
title_fullStr DYT1 dystonia increases risk taking in humans
title_full_unstemmed DYT1 dystonia increases risk taking in humans
title_short DYT1 dystonia increases risk taking in humans
title_sort dyt1 dystonia increases risk taking in humans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951192/
https://www.ncbi.nlm.nih.gov/pubmed/27249418
http://dx.doi.org/10.7554/eLife.14155
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