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The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis. LBR mutant derivatives implicated in Greenberg skeletal dysplasia or Pelger-Huët anomaly fail to...

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Detalles Bibliográficos
Autores principales:	Tsai, Pei-Ling, Zhao, Chenguang, Turner, Elizabeth, Schlieker, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951196/ https://www.ncbi.nlm.nih.gov/pubmed/27336722 http://dx.doi.org/10.7554/eLife.16011

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