Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcription. The first active transcriptional profiles from...

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Detalles Bibliográficos
Autores principales: Heinäniemi, Merja, Vuorenmaa, Tapio, Teppo, Susanna, Kaikkonen, Minna U, Bouvy-Liivrand, Maria, Mehtonen, Juha, Niskanen, Henri, Zachariadis, Vasilios, Laukkanen, Saara, Liuksiala, Thomas, Teittinen, Kaisa, Lohi, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951197/
https://www.ncbi.nlm.nih.gov/pubmed/27431763
http://dx.doi.org/10.7554/eLife.13087

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