Epidermal RAF prevents allergic skin disease

The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoti...

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Detalles Bibliográficos
Autores principales: Raguz, Josipa, Jeric, Ines, Niault, Theodora, Nowacka, Joanna Daniela, Kuzet, Sanya Eduarda, Rupp, Christian, Fischer, Irmgard, Biggi, Silvia, Borsello, Tiziana, Baccarini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951198/
https://www.ncbi.nlm.nih.gov/pubmed/27431613
http://dx.doi.org/10.7554/eLife.14012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951198/
https://www.ncbi.nlm.nih.gov/pubmed/27431613
http://dx.doi.org/10.7554/eLife.14012

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