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Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS

We determined whether the myelofibrosis drug ruxolitinib, an inhibitor of Janus kinases 1/2 (JAK1 and JAK2), could interact with the multiple sclerosis drug dimethyl-fumarate (DMF) to kill tumor cells; studies used the in vivo active form of the drug, mono-methyl fumarate (MMF). Ruxolitinib interact...

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Detalles Bibliográficos
Autores principales:	Tavallai, Mehrad, Booth, Laurence, Roberts, Jane L., McGuire, William P., Poklepovic, Andrew, Dent, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951212/ https://www.ncbi.nlm.nih.gov/pubmed/26981780 http://dx.doi.org/10.18632/oncotarget.8039

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