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Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients

Folate receptor alpha (FRα) is known to be upregulated in a variety of cancers, including non-small cell lung cancer (NSCLC) and breast cancer. To ensure reliable implementation of diagnostic- and therapeutic agents, concordance of FRα expression between biopsy, primary tumor and metastases is impor...

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Autores principales: Boogerd, Leonora S. F., Boonstra, Martin C., Beck, Ann-Jean, Charehbili, Ayoub, Hoogstins, Charlotte E.S., Prevoo, Hendrica A. J. M., Singhal, Sunil, Low, Philip S., van de Velde, Cornelis J. H., Vahrmeijer, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951224/
https://www.ncbi.nlm.nih.gov/pubmed/26943581
http://dx.doi.org/10.18632/oncotarget.7856
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author Boogerd, Leonora S. F.
Boonstra, Martin C.
Beck, Ann-Jean
Charehbili, Ayoub
Hoogstins, Charlotte E.S.
Prevoo, Hendrica A. J. M.
Singhal, Sunil
Low, Philip S.
van de Velde, Cornelis J. H.
Vahrmeijer, Alexander L.
author_facet Boogerd, Leonora S. F.
Boonstra, Martin C.
Beck, Ann-Jean
Charehbili, Ayoub
Hoogstins, Charlotte E.S.
Prevoo, Hendrica A. J. M.
Singhal, Sunil
Low, Philip S.
van de Velde, Cornelis J. H.
Vahrmeijer, Alexander L.
author_sort Boogerd, Leonora S. F.
collection PubMed
description Folate receptor alpha (FRα) is known to be upregulated in a variety of cancers, including non-small cell lung cancer (NSCLC) and breast cancer. To ensure reliable implementation of diagnostic- and therapeutic agents, concordance of FRα expression between biopsy, primary tumor and metastases is important. Using immunohistochemistry (Mab 26B3.F2) these concordances were investigated in 60 NSCLC and 40 breast cancer patients. False positivity of FRα expression on breast and lung cancer biopsies was limited to less than 5%. In NSCLC, FRα expression was shown in 21/34 adenocarcinomas and 4/26 squamous cell carcinomas (SCC). Concordance of FRα expression between biopsy and primary tumor was achieved in respectively 83% and 91% of adenocarcinomas and SCCs. Approximately 80% of all local and distant metastases of NSCLC patients showed concordant FRα expression as their corresponding primary tumor. In breast cancer, FRα positivity was shown in 12/40 biopsies, 20/40 lumpectomies and 6/20 LN metastases, with concordance of 68% between biopsy and primary tumor and 60% between primary tumor and LN metastases. In conclusion, this study shows high concordance rates of FRα expression between biopsies and metastases compared to primary NSCLC and breast cancers, underscoring the applicability of FRα-targeted agents in these patients.
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spelling pubmed-49512242016-07-21 Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients Boogerd, Leonora S. F. Boonstra, Martin C. Beck, Ann-Jean Charehbili, Ayoub Hoogstins, Charlotte E.S. Prevoo, Hendrica A. J. M. Singhal, Sunil Low, Philip S. van de Velde, Cornelis J. H. Vahrmeijer, Alexander L. Oncotarget Research Paper: Pathology Folate receptor alpha (FRα) is known to be upregulated in a variety of cancers, including non-small cell lung cancer (NSCLC) and breast cancer. To ensure reliable implementation of diagnostic- and therapeutic agents, concordance of FRα expression between biopsy, primary tumor and metastases is important. Using immunohistochemistry (Mab 26B3.F2) these concordances were investigated in 60 NSCLC and 40 breast cancer patients. False positivity of FRα expression on breast and lung cancer biopsies was limited to less than 5%. In NSCLC, FRα expression was shown in 21/34 adenocarcinomas and 4/26 squamous cell carcinomas (SCC). Concordance of FRα expression between biopsy and primary tumor was achieved in respectively 83% and 91% of adenocarcinomas and SCCs. Approximately 80% of all local and distant metastases of NSCLC patients showed concordant FRα expression as their corresponding primary tumor. In breast cancer, FRα positivity was shown in 12/40 biopsies, 20/40 lumpectomies and 6/20 LN metastases, with concordance of 68% between biopsy and primary tumor and 60% between primary tumor and LN metastases. In conclusion, this study shows high concordance rates of FRα expression between biopsies and metastases compared to primary NSCLC and breast cancers, underscoring the applicability of FRα-targeted agents in these patients. Impact Journals LLC 2016-03-02 /pmc/articles/PMC4951224/ /pubmed/26943581 http://dx.doi.org/10.18632/oncotarget.7856 Text en Copyright: © 2016 Boogerd et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Pathology
Boogerd, Leonora S. F.
Boonstra, Martin C.
Beck, Ann-Jean
Charehbili, Ayoub
Hoogstins, Charlotte E.S.
Prevoo, Hendrica A. J. M.
Singhal, Sunil
Low, Philip S.
van de Velde, Cornelis J. H.
Vahrmeijer, Alexander L.
Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title_full Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title_fullStr Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title_full_unstemmed Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title_short Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
title_sort concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
topic Research Paper: Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951224/
https://www.ncbi.nlm.nih.gov/pubmed/26943581
http://dx.doi.org/10.18632/oncotarget.7856
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