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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting

Ewing sarcoma is an aggressive primary pediatric bone tumor, often diagnosed in adolescents and young adults. A pathognomonic reciprocal chromosomal translocation results in a fusion gene coding for a protein which derives its N-terminus from a FUS/EWS/TAF15 (FET) protein family member, commonly EWS...

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Detalles Bibliográficos
Autores principales:	Theisen, Emily R., Pishas, Kathleen I., Saund, Ranajeet S., Lessnick, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951237/ https://www.ncbi.nlm.nih.gov/pubmed/26848860 http://dx.doi.org/10.18632/oncotarget.7124

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