Cargando…

β(2)-Adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α

Cigarette smoking is a risk factor for pancreatic cancer. It is suggested that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, mediates the carcinogenic action of cigarette smoking by promoting cancer growth. In the present study, we show that smoking, HIF-1α ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Dong, Lei, Jianjun, Ma, Jiguang, Chen, Xin, Sheng, Liang, Jiang, Zhengdong, Nan, Ligang, Xu, Qinhong, Duan, Wanxing, Wang, Zheng, Li, Xuqi, Wu, Zheng, Wu, Erxi, Ma, Qingyong, Huo, Xiongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951248/ https://www.ncbi.nlm.nih.gov/pubmed/26497365 http://dx.doi.org/10.18632/oncotarget.5677

Ejemplares similares

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway
por: Duan, Wanxing, et al.
Publicado: (2015)

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
por: Ma, Jiguang, et al.
Publicado: (2015)

Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer
por: Li, Wei, et al.
Publicado: (2015)

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
por: Lei, Jianjun, et al.
Publicado: (2013)

α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
por: Xu, Qinhong, et al.
Publicado: (2014)

Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway
por: Han, Liang, et al.
Publicado: (2016)

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases
por: Xu, Qinhong, et al.
Publicado: (2015)

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
por: Xu, Qinhong, et al.
Publicado: (2014)

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
por: Jiang, Zhengdong, et al.
Publicado: (2018)

Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK
por: HUANG, XIN, et al.
Publicado: (2015)

Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK
por: Huang, Xin, et al.
Publicado: (2023)

Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
por: Zong, Liang, et al.
Publicado: (2017)

Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation
por: Xiao, Ying, et al.
Publicado: (2020)

Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1
por: Zhou, Cancan, et al.
Publicado: (2018)

NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer
por: Qin, Tao, et al.
Publicado: (2020)

High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer
por: Zhou, Cancan, et al.
Publicado: (2019)

Hyperglycemia, a Neglected Factor during Cancer Progression
por: Duan, Wanxing, et al.
Publicado: (2014)

The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species
por: Zhang, Lun, et al.
Publicado: (2016)

Editorial: The Microenvironment in Pancreatic Cancer and Therapeutic Strategies Targeting Microenvironment
por: Duan, Wanxing, et al.
Publicado: (2022)

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
por: Sun, Liankang, et al.
Publicado: (2018)

Pancreatic carcinoma-specific immunotherapy using novel tumor specific cytotoxic T cells
por: Lei, Jianjun, et al.
Publicado: (2016)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia
por: Chen, Xin, et al.
Publicado: (2021)

Disrupting the Balance between Tumor Epithelia and Stroma is a Possible Therapeutic Approach for Pancreatic Cancer
por: Wang, Zheng, et al.
Publicado: (2014)

PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway
por: Wang, Xiu, et al.
Publicado: (2015)

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine
por: Jiang, Zhengdong, et al.
Publicado: (2016)

Lipoxin A(4) Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
por: Zong, Liang, et al.
Publicado: (2016)

Cav-1 Ablation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Growth through Nrf2-Induced shh Signaling
por: Shao, Shan, et al.
Publicado: (2020)

Pancreatic Stellate Cells Facilitate Perineural Invasion of Pancreatic Cancer via HGF/c-Met Pathway
por: Nan, Ligang, et al.
Publicado: (2019)

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy
por: Chen, Xin, et al.
Publicado: (2022)

Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF
por: Shao, Shan, et al.
Publicado: (2019)

Potent Antitumor Activity Generated by a Novel Tumor Specific Cytotoxic T Cell
por: Wang, Zheng, et al.
Publicado: (2013)

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
por: Qian, Weikun, et al.
Publicado: (2021)

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling
por: Liu, Jiangbo, et al.
Publicado: (2014)

Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer
por: Zhang, Lun, et al.
Publicado: (2016)

Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1‐dependent pathway
por: Chen, Ke, et al.
Publicado: (2017)

High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR
por: Han, Liang, et al.
Publicado: (2011)

Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives
por: Jiang, Zhengdong, et al.
Publicado: (2019)

NNK-Induced Lung Tumors: A Review of Animal Model
por: Zheng, Hua-Chuan, et al.
Publicado: (2011)

Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1
por: Cao, Junyu, et al.
Publicado: (2018)

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
por: Chen, Xin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fbmrr6tq7hoa5p08aq55n4f9qj