Cargando…

Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder promoted by the constitutive tyrosine kinase activity of Bcr-Abl oncoprotein. Although treatment with the Bcr-Abl-inhibitor imatinib represents the first-line therapy against CML, almost 20-30% of patients develop chemotherapeutic resi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salizzato, Valentina, Borgo, Christian, Cesaro, Luca, Pinna, Lorenzo A., Donella-Deana, Arianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951282/ https://www.ncbi.nlm.nih.gov/pubmed/26919095 http://dx.doi.org/10.18632/oncotarget.7569

Ejemplares similares

Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells
por: Zanin, Sofia, et al.
Publicado: (2012)

CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity
por: Borgo, Christian, et al.
Publicado: (2017)

Generation and quantitative proteomics analysis of CK2α/α’((−/−)) cells
por: Borgo, Christian, et al.
Publicado: (2017)

Exploring the CK2 Paradox: Restless, Dangerous, Dispensable
por: Franchin, Cinzia, et al.
Publicado: (2017)

RpS3 Is Required for Spermatogenesis of Drosophila melanogaster
por: Fang, Yang, et al.
Publicado: (2023)

Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene
por: Ahn, Woo Sung, et al.
Publicado: (2023)

Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy – potential clinical relevance
por: D’Amore, Claudio, et al.
Publicado: (2020)

RP1 Is a Phosphorylation Target of CK2 and Is Involved in Cell Adhesion
por: Stenner, Frank, et al.
Publicado: (2013)

Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells
por: Grundy, Martin, et al.
Publicado: (2018)

White Adipose Tissue Expansion in Multiple Symmetric Lipomatosis Is Associated with Upregulation of CK2, AKT and ERK1/2
por: Sanna, Marta, et al.
Publicado: (2020)

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB
por: Girardi, Cristina, et al.
Publicado: (2015)

Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation
por: Ang, Zhiwei, et al.
Publicado: (2019)

Analysis of the phosphoproteome of CK2α((–/–))/Δα′ C2C12 myoblasts compared to the wild-type cells
por: Borgo, Christian, et al.
Publicado: (2023)

An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome
por: Jiao, Jianqin, et al.
Publicado: (2021)

Targeting CK2 in cancer: a valuable strategy or a waste of time?
por: Salvi, Mauro, et al.
Publicado: (2021)

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1
por: Ji, Zhejun, et al.
Publicado: (2019)

Production, characterization, and epitope mapping of monoclonal antibodies of ribosomal protein S3 (rpS3)
por: Ahn, Woo-Sung, et al.
Publicado: (2021)

High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.
por: Watcho, Pierre, et al.
Publicado: (2010)

Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice
por: Ferrer-Font, Laura, et al.
Publicado: (2017)

Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation
por: Minakhina, Svetlana, et al.
Publicado: (2016)

RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis
por: Kim, Wanyeon, et al.
Publicado: (2018)

Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated
por: Kim, YongJoong, et al.
Publicado: (2016)

RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells
por: Zhang, Shuai, et al.
Publicado: (2020)

CK1δ Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation
por: Bischof, Joachim, et al.
Publicado: (2013)

Role of protein kinase CK2 in antitumor drug resistance
por: Borgo, Christian, et al.
Publicado: (2019)

Overexpression of RPS27a contributes to enhanced chemoresistance of CML cells to imatinib by the transactivated STAT3
por: Wang, Houcai, et al.
Publicado: (2016)

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit
por: Montellese, Christian, et al.
Publicado: (2020)

Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
por: Li, Lin-Xi, et al.
Publicado: (2019)

CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism
por: Lertsuwan, Jomnarong, et al.
Publicado: (2018)

Phosphoproteomic Landscape of AML Cells Treated with the ATP-Competitive CK2 Inhibitor CX-4945
por: Rosales, Mauro, et al.
Publicado: (2021)

Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells
por: Zonta, Francesca, et al.
Publicado: (2021)

Managing chronic myeloid leukaemia in the elderly with intermittent imatinib treatment
por: Russo, D, et al.
Publicado: (2015)

Rotating between ponatinib and imatinib temporarily increases the efficacy of imatinib as shown in a chronic myeloid leukaemia model
por: Lindström, H. Jonathan G., et al.
Publicado: (2022)

RpS13 controls the homeostasis of germline stem cell niche through Rho1‐mediated signals in the Drosophila testis
por: Wang, Min, et al.
Publicado: (2020)

Structural Determinants of CX-4945 Derivatives as Protein Kinase CK2 Inhibitors: A Computational Study
por: Liu, Hongbo, et al.
Publicado: (2011)

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia
por: Klink, Morgann, et al.
Publicado: (2021)

Disease acceptance and adherence to imatinib in Taiwanese chronic myeloid leukaemia outpatients
por: Chen, Li-Chia, et al.
Publicado: (2013)

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP
por: Bartley, Christopher M., et al.
Publicado: (2016)

A Local Role for the Small Ribosomal Subunit Primary Binder rpS5 in Final 18S rRNA Processing in Yeast
por: Neueder, Andreas, et al.
Publicado: (2010)

Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion
por: Babendreyer, Aaron, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hv6h22bl70gaittjgjut3c8ipa