A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth

Human epidermal growth factor receptor 2 (HER2 or ErBb2) is a receptor tyrosine kinase overexpressed in 20-30% of breast cancers and associated with poor prognosis and outcome. Dysregulation of several microRNAs (miRNAs) plays a key role in breast cancer progression and metastasis. In this study, we...

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Detalles Bibliográficos
Autores principales: Patel, Yogin, Shah, Nirav, Lee, Ji Shin, Markoutsa, Eleni, Jie, Chunfa, Liu, Shou, Botbyl, Rachel, Reisman, David, Xu, Peisheng, Chen, Hexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951289/
https://www.ncbi.nlm.nih.gov/pubmed/26918448
http://dx.doi.org/10.18632/oncotarget.7577

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