A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells

Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members of the vertebrate secreted ribonuclease family are not cytotoxic because they are not able to evade the cytosolic ribonuclease inhibitor. We previously engineered the human pancreatic ribonuclease to...

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Detalles Bibliográficos
Autores principales: Vert, Anna, Castro, Jessica, Ribó, Marc, Benito, Antoni, Vilanova, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951290/
https://www.ncbi.nlm.nih.gov/pubmed/26918450
http://dx.doi.org/10.18632/oncotarget.7579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951290/
https://www.ncbi.nlm.nih.gov/pubmed/26918450
http://dx.doi.org/10.18632/oncotarget.7579

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