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A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells
Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members of the vertebrate secreted ribonuclease family are not cytotoxic because they are not able to evade the cytosolic ribonuclease inhibitor. We previously engineered the human pancreatic ribonuclease to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951290/ https://www.ncbi.nlm.nih.gov/pubmed/26918450 http://dx.doi.org/10.18632/oncotarget.7579 |