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eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells

Clusterin is a secretory heterodimeric glycoprotein and the overexpression of secretory clusterin (sCLU) promotes cancer cell proliferation and reduces chemosensitivity. Therefore, sCLU might be an effective target for anticancer therapy. In the current study, we identified eIF3f as a novel CLU-inte...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Yeon, Kim, Hyun-Ji, Rho, Seung Bae, Lee, Seung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951308/
https://www.ncbi.nlm.nih.gov/pubmed/26988917
http://dx.doi.org/10.18632/oncotarget.8105