Overexpression of RPS27a contributes to enhanced chemoresistance of CML cells to imatinib by the transactivated STAT3

STAT3 plays a pivotal role in the hematopoietic system, which constitutively activated by BCR–ABL via JAK and Erk/MAP-kinase pathways. Phospho-STAT3 was overexpressed in imatinib-resistant CML patients as relative to imatinib responsive ones. By activation of the STAT3 pathway, BCR–ABL can promote c...

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Detalles Bibliográficos
Autores principales: Wang, Houcai, Xie, Bingqian, Kong, Yuanyuan, Tao, Yi, Yang, Guang, Gao, Minjie, Xu, Hongwei, Zhan, Fenghuang, Shi, Jumei, Zhang, Yiwen, Wu, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951316/
https://www.ncbi.nlm.nih.gov/pubmed/26942564
http://dx.doi.org/10.18632/oncotarget.7888

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