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Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study

Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors. Thirty-onepatients with RIBP after radiotherapy for NPC...

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Autores principales: Cai, Zhaoxi, Li, Yi, Hu, Zhen, Fu, Ruying, Rong, Xiaoming, Wu, Rong, Cheng, Jinping, Huang, Xiaolong, Luo, Jinjun, Tang, Yamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951337/
https://www.ncbi.nlm.nih.gov/pubmed/26934119
http://dx.doi.org/10.18632/oncotarget.7748
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author Cai, Zhaoxi
Li, Yi
Hu, Zhen
Fu, Ruying
Rong, Xiaoming
Wu, Rong
Cheng, Jinping
Huang, Xiaolong
Luo, Jinjun
Tang, Yamei
author_facet Cai, Zhaoxi
Li, Yi
Hu, Zhen
Fu, Ruying
Rong, Xiaoming
Wu, Rong
Cheng, Jinping
Huang, Xiaolong
Luo, Jinjun
Tang, Yamei
author_sort Cai, Zhaoxi
collection PubMed
description Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors. Thirty-onepatients with RIBP after radiotherapy for NPC were enrolled. Clinical manifestations of RIBP, electrophysiologic data, magnetic resonance imaging (MRI), and the correlation between irradiation strategy and incidence of RIBP were evaluated. The mean latency at the onset of RIBP was 4.26 years. Of the symptoms, paraesthesia usually presented first (51.6%), followed by pain (22.6%) and weakness (22.6%). The major symptoms included paraesthesia (90.3%), pain (54.8%), weakness (48.4%), fasciculation (19.3%) and muscle atrophy (9.7%). Nerve conduction velocity (NCV) and electromyography (EMG) disclosed that pathological changes of brachial plexus involved predominantly in the upper and middle trunks in distribution. MRI of the brachial plexus showed hyper-intensity on T1, T2, post-contrast T1 and diffusion weighted whole body imaging with background body signal suppression (DWIBS) images in lower cervical nerves. Radiotherapy with Gross Tumor volume (GTVnd) and therapeutic dose (mean 66.8±2.8Gy) for patients with lower cervical lymph node metastasis was related to a significantly higher incidence of RIBP (P<0.001). Thus, RIBP is a severe and progressive complication of NPC after radiotherapy. The clinical symptoms are predominantly involved in upper and middle trunk of the brachial plexus in distribution. Lower cervical lymph node metastasis and corresponding radiotherapy might cause a significant increase of the RIBP incidence.
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spelling pubmed-49513372016-07-21 Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study Cai, Zhaoxi Li, Yi Hu, Zhen Fu, Ruying Rong, Xiaoming Wu, Rong Cheng, Jinping Huang, Xiaolong Luo, Jinjun Tang, Yamei Oncotarget Research Paper Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors. Thirty-onepatients with RIBP after radiotherapy for NPC were enrolled. Clinical manifestations of RIBP, electrophysiologic data, magnetic resonance imaging (MRI), and the correlation between irradiation strategy and incidence of RIBP were evaluated. The mean latency at the onset of RIBP was 4.26 years. Of the symptoms, paraesthesia usually presented first (51.6%), followed by pain (22.6%) and weakness (22.6%). The major symptoms included paraesthesia (90.3%), pain (54.8%), weakness (48.4%), fasciculation (19.3%) and muscle atrophy (9.7%). Nerve conduction velocity (NCV) and electromyography (EMG) disclosed that pathological changes of brachial plexus involved predominantly in the upper and middle trunks in distribution. MRI of the brachial plexus showed hyper-intensity on T1, T2, post-contrast T1 and diffusion weighted whole body imaging with background body signal suppression (DWIBS) images in lower cervical nerves. Radiotherapy with Gross Tumor volume (GTVnd) and therapeutic dose (mean 66.8±2.8Gy) for patients with lower cervical lymph node metastasis was related to a significantly higher incidence of RIBP (P<0.001). Thus, RIBP is a severe and progressive complication of NPC after radiotherapy. The clinical symptoms are predominantly involved in upper and middle trunk of the brachial plexus in distribution. Lower cervical lymph node metastasis and corresponding radiotherapy might cause a significant increase of the RIBP incidence. Impact Journals LLC 2016-02-26 /pmc/articles/PMC4951337/ /pubmed/26934119 http://dx.doi.org/10.18632/oncotarget.7748 Text en Copyright: © 2016 Cai et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Cai, Zhaoxi
Li, Yi
Hu, Zhen
Fu, Ruying
Rong, Xiaoming
Wu, Rong
Cheng, Jinping
Huang, Xiaolong
Luo, Jinjun
Tang, Yamei
Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title_full Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title_fullStr Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title_full_unstemmed Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title_short Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
title_sort radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951337/
https://www.ncbi.nlm.nih.gov/pubmed/26934119
http://dx.doi.org/10.18632/oncotarget.7748
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