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SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation

Skp2 is a component of the E3 ubiquitin ligase which promotes the ubiquitination-associated degradation of a cyclin-dependent kinase inhibitor, p27, resulting in increases in non-small cell lung cancer (NSCLC) cell growth. We recently showed that down-regulation of Sirtuin deacetylases 2 (SIRT2) in...

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Detalles Bibliográficos
Autores principales:	Li, Ziming, Huang, Jia, Yuan, Hong, Chen, Zhiwei, Luo, Qingquan, Lu, Shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951341/ https://www.ncbi.nlm.nih.gov/pubmed/26942878 http://dx.doi.org/10.18632/oncotarget.7816

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