In Vitro Activity of Tigecycline Against Orientia tsutsugamushi

Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a...

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Autores principales: Lee, Sun-Myoung, Kwon, Hae-Yoon, Im, Jae-Hyoung, Baek, Ji Hyeon, Hwang, Seung-Sik, Kang, Jae-Seung, Chung, Moon-Hyun, Lee, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951447/
https://www.ncbi.nlm.nih.gov/pubmed/27189302
http://dx.doi.org/10.3349/ymj.2016.57.4.1034
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author Lee, Sun-Myoung
Kwon, Hae-Yoon
Im, Jae-Hyoung
Baek, Ji Hyeon
Hwang, Seung-Sik
Kang, Jae-Seung
Chung, Moon-Hyun
Lee, Jin-Soo
author_facet Lee, Sun-Myoung
Kwon, Hae-Yoon
Im, Jae-Hyoung
Baek, Ji Hyeon
Hwang, Seung-Sik
Kang, Jae-Seung
Chung, Moon-Hyun
Lee, Jin-Soo
author_sort Lee, Sun-Myoung
collection PubMed
description Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC(50)) was 3.59×10(-3) µg/mL in doxycycline-treated group. Whereas in 0.71×10(-3) µg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus.
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spelling pubmed-49514472016-07-20 In Vitro Activity of Tigecycline Against Orientia tsutsugamushi Lee, Sun-Myoung Kwon, Hae-Yoon Im, Jae-Hyoung Baek, Ji Hyeon Hwang, Seung-Sik Kang, Jae-Seung Chung, Moon-Hyun Lee, Jin-Soo Yonsei Med J Brief Communication Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC(50)) was 3.59×10(-3) µg/mL in doxycycline-treated group. Whereas in 0.71×10(-3) µg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus. Yonsei University College of Medicine 2016-07-01 2016-05-10 /pmc/articles/PMC4951447/ /pubmed/27189302 http://dx.doi.org/10.3349/ymj.2016.57.4.1034 Text en © Copyright: Yonsei University College of Medicine 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Lee, Sun-Myoung
Kwon, Hae-Yoon
Im, Jae-Hyoung
Baek, Ji Hyeon
Hwang, Seung-Sik
Kang, Jae-Seung
Chung, Moon-Hyun
Lee, Jin-Soo
In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title_full In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title_fullStr In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title_full_unstemmed In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title_short In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
title_sort in vitro activity of tigecycline against orientia tsutsugamushi
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951447/
https://www.ncbi.nlm.nih.gov/pubmed/27189302
http://dx.doi.org/10.3349/ymj.2016.57.4.1034
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