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Research on the printability of hydrogels in 3D bioprinting
As the biocompatible materials, hydrogels have been widely used in three- dimensional (3D) bioprinting/organ printing to load cell for tissue engineering. It is important to precisely control hydrogels deposition during printing the mimic organ structures. However, the printability of hydrogels abou...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951698/ https://www.ncbi.nlm.nih.gov/pubmed/27436509 http://dx.doi.org/10.1038/srep29977 |
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author | He, Yong Yang, FeiFei Zhao, HaiMing Gao, Qing Xia, Bing Fu, JianZhong |
author_facet | He, Yong Yang, FeiFei Zhao, HaiMing Gao, Qing Xia, Bing Fu, JianZhong |
author_sort | He, Yong |
collection | PubMed |
description | As the biocompatible materials, hydrogels have been widely used in three- dimensional (3D) bioprinting/organ printing to load cell for tissue engineering. It is important to precisely control hydrogels deposition during printing the mimic organ structures. However, the printability of hydrogels about printing parameters is seldom addressed. In this paper, we systemically investigated the printability of hydrogels from printing lines (one dimensional, 1D structures) to printing lattices/films (two dimensional, 2D structures) and printing 3D structures with a special attention to the accurate printing. After a series of experiments, we discovered the relationships between the important factors such as air pressure, feedrate, or even printing distance and the printing quality of the expected structures. Dumbbell shape was observed in the lattice structures printing due to the hydrogel diffuses at the intersection. Collapses and fusion of adjacent layer would result in the error accumulation at Z direction which was an important fact that could cause printing failure. Finally, we successfully demonstrated a 3D printing hydrogel scaffold through harmonize with all the parameters. The cell viability after printing was compared with the casting and the results showed that our bioprinting method almost had no extra damage to the cells. |
format | Online Article Text |
id | pubmed-4951698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49516982016-07-26 Research on the printability of hydrogels in 3D bioprinting He, Yong Yang, FeiFei Zhao, HaiMing Gao, Qing Xia, Bing Fu, JianZhong Sci Rep Article As the biocompatible materials, hydrogels have been widely used in three- dimensional (3D) bioprinting/organ printing to load cell for tissue engineering. It is important to precisely control hydrogels deposition during printing the mimic organ structures. However, the printability of hydrogels about printing parameters is seldom addressed. In this paper, we systemically investigated the printability of hydrogels from printing lines (one dimensional, 1D structures) to printing lattices/films (two dimensional, 2D structures) and printing 3D structures with a special attention to the accurate printing. After a series of experiments, we discovered the relationships between the important factors such as air pressure, feedrate, or even printing distance and the printing quality of the expected structures. Dumbbell shape was observed in the lattice structures printing due to the hydrogel diffuses at the intersection. Collapses and fusion of adjacent layer would result in the error accumulation at Z direction which was an important fact that could cause printing failure. Finally, we successfully demonstrated a 3D printing hydrogel scaffold through harmonize with all the parameters. The cell viability after printing was compared with the casting and the results showed that our bioprinting method almost had no extra damage to the cells. Nature Publishing Group 2016-07-20 /pmc/articles/PMC4951698/ /pubmed/27436509 http://dx.doi.org/10.1038/srep29977 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article He, Yong Yang, FeiFei Zhao, HaiMing Gao, Qing Xia, Bing Fu, JianZhong Research on the printability of hydrogels in 3D bioprinting |
title | Research on the printability of hydrogels in 3D bioprinting |
title_full | Research on the printability of hydrogels in 3D bioprinting |
title_fullStr | Research on the printability of hydrogels in 3D bioprinting |
title_full_unstemmed | Research on the printability of hydrogels in 3D bioprinting |
title_short | Research on the printability of hydrogels in 3D bioprinting |
title_sort | research on the printability of hydrogels in 3d bioprinting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951698/ https://www.ncbi.nlm.nih.gov/pubmed/27436509 http://dx.doi.org/10.1038/srep29977 |
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