ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation

Elevated levels of the transcriptional regulators Yes-associated protein (YAP) and transcriptional coactivators with PDZ-binding motif (TAZ), key effectors of the Hippo pathway, have been shown to play essential roles in controlling liver cell fate and the activation of hepatic stellate cells (HSCs)...

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Detalles Bibliográficos
Autores principales: Zhang, Kun, Chang, Yanan, Shi, Zhemin, Han, Xiaohui, Han, Yawei, Yao, Qingbin, Hu, Zhimei, Cui, Hongmei, Zheng, Lina, Han, Tao, Hong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951777/
https://www.ncbi.nlm.nih.gov/pubmed/27435808
http://dx.doi.org/10.1038/srep30029

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