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Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle
BACKGROUND: The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy. However, how these therapies reduce the muscle fragility is not clear. METHOD...
Autores principales: | Roy, Pauline, Rau, Fredérique, Ochala, Julien, Messéant, Julien, Fraysse, Bodvael, Lainé, Jeanne, Agbulut, Onnik, Butler-Browne, Gillian, Furling, Denis, Ferry, Arnaud |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952281/ https://www.ncbi.nlm.nih.gov/pubmed/27441081 http://dx.doi.org/10.1186/s13395-016-0096-4 |
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