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Recurrent inactivating RASA2 mutations in melanoma
Analysis of 501 melanoma exomes revealed RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954601/ https://www.ncbi.nlm.nih.gov/pubmed/26502337 http://dx.doi.org/10.1038/ng.3427 |
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| author | Arafeh, Rand Qutob, Nouar Emmanuel, Rafi Keren-Paz, Alona Madore, Jason Elkahloun, Abdel Wilmott, James S. Gartner, Jared J. Di Pizio, Antonella Winograd-Katz, Sabina Sindiri, Sivasish Rotkopf, Ron Dutton-Regester, Ken Johansson, Peter Pritchard, Antonia Waddell, Nicola Hill, Victoria K. Lin, Jimmy C. Hevroni, Yael Rosenberg, Steven A. Khan, Javed Ben-Dor, Shifra Niv, Masha Y. Ulitsky, Igor Mann, Graham J Scolyer, Richard A. Hayward, Nicholas K. Samuels, Yardena |
| author_facet | Arafeh, Rand Qutob, Nouar Emmanuel, Rafi Keren-Paz, Alona Madore, Jason Elkahloun, Abdel Wilmott, James S. Gartner, Jared J. Di Pizio, Antonella Winograd-Katz, Sabina Sindiri, Sivasish Rotkopf, Ron Dutton-Regester, Ken Johansson, Peter Pritchard, Antonia Waddell, Nicola Hill, Victoria K. Lin, Jimmy C. Hevroni, Yael Rosenberg, Steven A. Khan, Javed Ben-Dor, Shifra Niv, Masha Y. Ulitsky, Igor Mann, Graham J Scolyer, Richard A. Hayward, Nicholas K. Samuels, Yardena |
| author_sort | Arafeh, Rand |
| collection | PubMed |
| description | Analysis of 501 melanoma exomes revealed RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings reveal RASA2 inactivation as a melanoma driver and highlight the importance of Ras GAPs in cancer. |
| format | Online Article Text |
| id | pubmed-4954601 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49546012016-07-20 Recurrent inactivating RASA2 mutations in melanoma Arafeh, Rand Qutob, Nouar Emmanuel, Rafi Keren-Paz, Alona Madore, Jason Elkahloun, Abdel Wilmott, James S. Gartner, Jared J. Di Pizio, Antonella Winograd-Katz, Sabina Sindiri, Sivasish Rotkopf, Ron Dutton-Regester, Ken Johansson, Peter Pritchard, Antonia Waddell, Nicola Hill, Victoria K. Lin, Jimmy C. Hevroni, Yael Rosenberg, Steven A. Khan, Javed Ben-Dor, Shifra Niv, Masha Y. Ulitsky, Igor Mann, Graham J Scolyer, Richard A. Hayward, Nicholas K. Samuels, Yardena Nat Genet Article Analysis of 501 melanoma exomes revealed RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings reveal RASA2 inactivation as a melanoma driver and highlight the importance of Ras GAPs in cancer. 2015-10-26 2015-12 /pmc/articles/PMC4954601/ /pubmed/26502337 http://dx.doi.org/10.1038/ng.3427 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Arafeh, Rand Qutob, Nouar Emmanuel, Rafi Keren-Paz, Alona Madore, Jason Elkahloun, Abdel Wilmott, James S. Gartner, Jared J. Di Pizio, Antonella Winograd-Katz, Sabina Sindiri, Sivasish Rotkopf, Ron Dutton-Regester, Ken Johansson, Peter Pritchard, Antonia Waddell, Nicola Hill, Victoria K. Lin, Jimmy C. Hevroni, Yael Rosenberg, Steven A. Khan, Javed Ben-Dor, Shifra Niv, Masha Y. Ulitsky, Igor Mann, Graham J Scolyer, Richard A. Hayward, Nicholas K. Samuels, Yardena Recurrent inactivating RASA2 mutations in melanoma |
| title | Recurrent inactivating RASA2 mutations in melanoma |
| title_full | Recurrent inactivating RASA2 mutations in melanoma |
| title_fullStr | Recurrent inactivating RASA2 mutations in melanoma |
| title_full_unstemmed | Recurrent inactivating RASA2 mutations in melanoma |
| title_short | Recurrent inactivating RASA2 mutations in melanoma |
| title_sort | recurrent inactivating rasa2 mutations in melanoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954601/ https://www.ncbi.nlm.nih.gov/pubmed/26502337 http://dx.doi.org/10.1038/ng.3427 |
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