Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

Neuroendocrine prostate cancer is a lethal variant of prostate cancer that is associated with castrate-resistant growth, metastasis, and mortality. The tumor environment of neuroendocrine prostate cancer is heterogeneous and characterized by hypoxia, necrosis, and numerous mitoses. Although acidic e...

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Detalles Bibliográficos
Autores principales: Ippolito, Joseph E., Brandenburg, Matthew W., Ge, Xia, Crowley, Jan R., Kirmess, Kristopher M., Som, Avik, D’Avignon, D. Andre, Arbeit, Jeffrey M., Achilefu, Samuel, Yarasheski, Kevin E., Milbrandt, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954648/
https://www.ncbi.nlm.nih.gov/pubmed/27438712
http://dx.doi.org/10.1371/journal.pone.0159675

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