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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic studies identified a locus on rat chromosome 9 that controls the susceptibility to neuroinflammati...

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Detalles Bibliográficos
Autores principales:	Kassem, Sahar, Gaud, Guillaume, Bernard, Isabelle, Benamar, Mehdi, Dejean, Anne S., Liblau, Roland, Fournié, Gilbert J., Colacios, Céline, Malissen, Bernard, Saoudi, Abdelhadi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954684/ https://www.ncbi.nlm.nih.gov/pubmed/27438086 http://dx.doi.org/10.1371/journal.pgen.1006185

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