XRN2 Links Transcription Termination to DNA Damage and Replication Stress

XRN2 is a 5’-3’ exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of DNA double-strand breaks (DSBs). We show that XRN2 undergoes DNA damage-inducible nuclear re...

Descripción completa

Detalles Bibliográficos
Autores principales: Morales, Julio C., Richard, Patricia, Patidar, Praveen L., Motea, Edward A., Dang, Tuyen T., Manley, James L., Boothman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954731/
https://www.ncbi.nlm.nih.gov/pubmed/27437695
http://dx.doi.org/10.1371/journal.pgen.1006107

Ejemplares similares

Ejemplares similares