A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies

Titin (TTN) is known as the largest sarcomeric protein that resides within the heart muscle. Due to alternative splicing of TTN, the heart expresses two major isoforms (N2B and N2BA) that incorporate four distinct regions termed the Z-line, I-band, A-band, and M-line. Next-generation sequencing allo...

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Detalles Bibliográficos
Autores principales: Gigli, Marta, Begay, Rene L., Morea, Gaetano, Graw, Sharon L., Sinagra, Gianfranco, Taylor, Matthew R. G., Granzier, Henk, Mestroni, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954824/
https://www.ncbi.nlm.nih.gov/pubmed/27493940
http://dx.doi.org/10.3389/fcvm.2016.00021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954824/
https://www.ncbi.nlm.nih.gov/pubmed/27493940
http://dx.doi.org/10.3389/fcvm.2016.00021

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