Cargando…
A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies
Titin (TTN) is known as the largest sarcomeric protein that resides within the heart muscle. Due to alternative splicing of TTN, the heart expresses two major isoforms (N2B and N2BA) that incorporate four distinct regions termed the Z-line, I-band, A-band, and M-line. Next-generation sequencing allo...
Autores principales: | Gigli, Marta, Begay, Rene L., Morea, Gaetano, Graw, Sharon L., Sinagra, Gianfranco, Taylor, Matthew R. G., Granzier, Henk, Mestroni, Luisa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954824/ https://www.ncbi.nlm.nih.gov/pubmed/27493940 http://dx.doi.org/10.3389/fcvm.2016.00021 |
Ejemplares similares
-
Role of Titin Missense Variants in Dilated Cardiomyopathy
por: Begay, Rene L., et al.
Publicado: (2015) -
The Giant Protein Titin’s Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease
por: Tharp, Charles A., et al.
Publicado: (2019) -
Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure
por: Tharp, Charles, et al.
Publicado: (2020) -
Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner
por: Fukuda, Norio, et al.
Publicado: (2005) -
The giant protein titin regulates the length of the striated muscle thick filament
por: Tonino, Paola, et al.
Publicado: (2017)